| Title |
Variation of clinical manifestations according to culprit drugs in DRESS syndrome.
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| Author |
Da Woon Sim, Ji Eun Yu, Jiung Jeong, Jae-Woo Jung, Hye-Ryun Kang, Dong Yoon Kang, Young Min Ye, Young-Koo Jee, Sujeong Kim, Jung-Won Park, Min Gyu Kang, Sae Hoon Kim, Hye-Kyung Park, Min-Suk Yang, Gyu-Young Hur, Jun Kyu Lee, Jeong-Hee Choi, Yong Eun Kwon, Young-Il Koh, Korean Severe Cutaneous Adverse Reactions Consortium
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| Journal |
Pharmacoepidemiology and Drug Safety
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| Year |
2019
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| Vol/Issue/Page |
28:840-848.
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| File |
Variation of clinical manifestations according to culprit drugs in DRESS syndrome_Pharmacoepidemiology and Drug Safety.pdf (470 KB)
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| Abstract |
Purpose: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare but serious condition that systematically damages various internal organs through T-cell-mediated immunological drug reactions. We aimed to investigate whether clinical manifestations of DRESS syndrome differ according to culprit drugs.
Methods: We retrospectively analyzed data from 123 patients with probable/definite DRESS syndrome based on the RegiSCAR criteria (January 2011 to July 2016). The data were obtained from the Korean Severe Cutaneous Adverse Reaction Registry. Causality was assessed using the World Health Organization-Uppsala Monitoring Centre criteria. The culprit drugs were categorized as allopurinol, carbamazepine, anti-tuberculosis drug, vancomycin, cephalosporins, dapsone, and nonsteroidal anti-inflammatory drugs.
Results: Differences were observed among culprit drugs regarding the frequencies of hepatitis (P < 0.01), renal dysfunction (P < 0.0001), lymphadenopathy (P < 0.01), and atypical lymphocyte (P < 0.01). Latency period differed among culprit drugs (P < 0.0001), being shorter in vancomycin and cephalosporin. In terms of clinical severity, admission duration (P < 0.01) and treatment duration (P < 0.05) differed among culprit drugs, being longer in vancomycin and anti-tuberculosis drugs, respectively.
Conclusions: Based on the findings, clinical manifestations, including latency period and clinical severity, may differ according to culprit drugs in DRESS syndrome.
Keywords: biological variation; drug hypersensitivity syndrome; pharmacoepidemiology; symptom assessment.
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